Recommended dose: 150-600 mg daily given in 2 or 3 divided doses.
Neuropathic pain Initially 150 mg daily. May be increased to 300 mg daily after a 3-7 day interval. Max: 600 mg daily after an additional 7-day interval.
Epilepsy Initially 150 mg daily. May be increased to 300 mg daily after 1 wk. Max: 600 mg daily after an additional wk.
Generalized anxiety disorder 150-600 mg daily given in 2 or 3 divided doses. Initially 150 mg daily. May be increased to 300 mg daily after 1 wk. Following an additional wk, dose may be increased to 450 mg daily. Max: 600 mg daily after an additional wk.
Fibromyalgia Usual dose range: 300-450 mg daily in 2 divided doses. Initially 75 mg bid, may be increased to 150 mg bid w/in 1 wk.
Patients who do not experience sufficient benefit May further increase to 225 mg bid. Max: 600 mg daily after an additional wk.
Renal impairment CrCl ≥60 mL/min 150 mg bid or tid, 300 mg bid or tid, 450 mg bid or tid, 600 mg bid or tid,
30-60 mL/min 75 mg bid or tid, 150 mg bid or tid, 225 mg bid or tid, 300 mg bid or tid,
15-30 mL/min 25-50 mg once daily or bid, 75 mg once daily or bid, 100-150 mg once daily or bid, 150 mg once daily or bid,
<15 mL/min 25 mg once daily, 25-50 mg once daily, 50-75 mg once daily, 75 mg once daily.
Supplementary dose following hemodialysis 25 mg as single dose. Max: 100 mg as single dose.